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KMID : 0360419700060010027
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Korean Journal of Pharmacology
1970 Volume.6 No. 1 p.27 ~ p.35
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Syrosingopine and Reserpine on Pressor Action of Norepinephrine in Rabbits
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Abstract
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1) In whole anesthetized rabbits and spinal rabbits, the potentiating effort of syrosingopine and reserpine on pressor action of norepinephrine (NE) was compared.
2) The doses of syrosingopine and reserpine were 8, 40, 200 ㎍ and 1 mg per kg of body weight. The Pressor responses to NE(0.01, 0.05, 0.25, 1.2, 6.0, 30.0, 150.0 ㎍/kg) were examined at 4, 10 and 24 hours after administration of the drugs.
3) In whole rabbits, potentiation by syrosingopine of pressor effect of NE was observed after administration of above the dose of 40 ㎍/kg, potentiation by reserpine was above 8 ㎍/kg. The maximal potentiation was achieved 10 hours after administration of 200 ㎍/kg of each agent.
4) In spinal rabbits, syrosingopine (200 ㎍/kg) produced slight potentiation of pressor effect of NE. The same dose of reserpine produced more pronounced potentiation.
5) In the whole rabbits carbachol inhibited the potentiation observed 4 hours after administration of 40 ㎍/kg of reserpine and syrosingopine.
6) In spinal rabbits, the potentiation observed 10 hours after 200 ㎍/kg of reserpine and syrosingopine was inhibited by administration of carbachol.
7) The onset of potentiation of the pressor effect of NE was within 15 min after administration of syrosingopine and reserpine (1 mg/kg, each).
8) The above data suggest that the development of NE supersensitivity by syrosingopine and reserpine in rabbits has more intimate relationship with the decrease of central catecholamine contents than with that of peripheral ones. The depression of central sympathetic tone produced by these agents seems to play an important role in development of supersensitivity.
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